"Ambry Genetics"[submitter] AND "STK11"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 186562	NM_000455.5(STK11):c.-5C>T	STK11	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 627831	NM_000455.5(STK11):c.-4C>T	STK11	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 328228	NM_000455.5(STK11):c.-2G>T	STK11	Single nucleotide variant (5 prime UTR variant +1 more)	not specified +3 more	GConflicting classifications of pathogenicity
Select item 185127	NM_000455.5(STK11):c.-1C>T	STK11	Single nucleotide variant (5 prime UTR variant +1 more)	Breast and/or ovarian cancer +4 more	GConflicting classifications of pathogenicity
Select item 649900	NM_000455.5(STK11):c.4G>C (p.Glu2Gln)	STK11 (E2Q)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 492547	NM_000455.5(STK11):c.5A>C (p.Glu2Ala)	STK11 (E2A)	Single nucleotide variant (missense variant)	Melanoma, cutaneous malignant, susceptibility to, 1 +3 more	GUncertain significance
Select item 485011	NM_000455.5(STK11):c.6G>A (p.Glu2=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 920914	NM_000455.5(STK11):c.7G>C (p.Val3Leu)	STK11 (V3L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 419872	NM_000455.5(STK11):c.7G>A (p.Val3Met)	STK11 (V3M)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +3 more	GUncertain significance
Select item 328229	NM_000455.5(STK11):c.8T>G (p.Val3Gly)	STK11 (V3G)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 527859	NM_000455.5(STK11):c.9G>A (p.Val3=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 1051732	NM_000455.5(STK11):c.10G>C (p.Val4Leu)	STK11 (V4L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 480709	NM_000455.5(STK11):c.10G>A (p.Val4Met)	STK11 (V4M)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 1747221	NM_000455.5(STK11):c.11T>G (p.Val4Gly)	STK11 (V4G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1042673	NM_000455.5(STK11):c.11T>C (p.Val4Ala)	STK11 (V4A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 2451999	NM_000455.5(STK11):c.12G>C (p.Val4=)	STK11	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 921128	NM_000455.5(STK11):c.12G>A (p.Val4=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +2 more	GLikely benign
Select item 1771767	NM_000455.5(STK11):c.13G>A (p.Asp5Asn)	STK11 (D5N)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 839522	NM_000455.5(STK11):c.14A>G (p.Asp5Gly)	STK11 (D5G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 184490	NM_000455.5(STK11):c.15C>T (p.Asp5=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 1403746	NM_000455.5(STK11):c.16C>T (p.Pro6Ser)	STK11 (P6S)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 943418	NM_000455.5(STK11):c.17C>T (p.Pro6Leu)	STK11 (P6L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 647785	NM_000455.5(STK11):c.17C>G (p.Pro6Arg)	STK11 (P6R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 527851	NM_000455.5(STK11):c.18G>C (p.Pro6=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 527816	NM_000455.5(STK11):c.22C>G (p.Gln8Glu)	STK11 (Q8E)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 821376	NM_000455.5(STK11):c.24G>T (p.Gln8His)	STK11 (Q8H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 234549	NM_000455.5(STK11):c.25C>G (p.Leu9Val)	STK11 (L9V)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +5 more	GUncertain significance
Select item 2585205	NM_000455.5(STK11):c.26T>C (p.Leu9Pro)	STK11 (L9P)	Single nucleotide variant (missense variant +1 more)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 1332451	NM_000455.5(STK11):c.27G>A (p.Leu9=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 231897	NM_000455.5(STK11):c.27G>C (p.Leu9=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 1797429	NM_000455.5(STK11):c.28G>A (p.Gly10Ser)	STK11 (G10S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 480724	NM_000455.5(STK11):c.30C>T (p.Gly10=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GConflicting classifications of pathogenicity
Select item 232823	NM_000455.5(STK11):c.30C>A (p.Gly10=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 573702	NM_000455.5(STK11):c.31A>T (p.Met11Leu)	STK11 (M11L)	Single nucleotide variant (missense variant)	not specified +3 more	GUncertain significance
Select item 233673	NM_000455.5(STK11):c.31A>G (p.Met11Val)	STK11 (M11V)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 1729965	NM_000455.5(STK11):c.32T>C (p.Met11Thr)	STK11 (M11T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 2586611	NM_000455.5(STK11):c.33G>C (p.Met11Ile)	STK11 (M11I)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1731034	NM_000455.5(STK11):c.33G>A (p.Met11Ile)	STK11 (M11I)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 230472	NM_000455.5(STK11):c.33G>T (p.Met11Ile)	STK11 (M11I)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 662432	NM_000455.5(STK11):c.38C>T (p.Thr13Met)	STK11 (T13M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 649016	NM_000455.5(STK11):c.39G>A (p.Thr13=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 185666	NM_000455.5(STK11):c.41A>G (p.Glu14Gly)	STK11 (E14G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2451997	NM_000455.5(STK11):c.42G>T (p.Glu14Asp)	STK11 (E14D)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 215738	NM_000455.5(STK11):c.42G>A (p.Glu14=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 403797	NM_000455.5(STK11):c.43G>A (p.Gly15Ser)	STK11 (G15S)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 458045	NM_000455.5(STK11):c.44G>A (p.Gly15Asp)	STK11 (G15D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 184033	NM_000455.5(STK11):c.45C>T (p.Gly15=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 391105	NM_000455.5(STK11):c.48G>A (p.Glu16=)	STK11	Single nucleotide variant (synonymous variant)	not provided +2 more	GLikely benign
Select item 1744666	NM_000455.5(STK11):c.49C>T (p.Leu17=)	STK11	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 458049	NM_000455.5(STK11):c.49C>G (p.Leu17Val)	STK11 (L17V)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +2 more	GUncertain significance
Select item 142223	NM_000455.5(STK11):c.52A>C (p.Met18Leu)	STK11 (M18L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 480712	NM_000455.5(STK11):c.53T>C (p.Met18Thr)	STK11 (M18T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 825783	NM_000455.5(STK11):c.54G>T (p.Met18Ile)	STK11 (M18I)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 480711	NM_000455.5(STK11):c.54G>A (p.Met18Ile)	STK11 (M18I)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 548908	NM_000455.5(STK11):c.56C>T (p.Ser19Leu)	STK11 (S19L)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 799623	NM_000455.5(STK11):c.57G>T (p.Ser19=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 184297	NM_000455.5(STK11):c.57G>C (p.Ser19=)	STK11	Single nucleotide variant (synonymous variant)	STK11-related condition +3 more	GBenign/Likely benign
Select item 583340	NM_000455.5(STK11):c.58G>A (p.Val20Met)	STK11 (V20M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 458055	NM_000455.5(STK11):c.58G>T (p.Val20Leu)	STK11 (V20L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 419256	NM_000455.5(STK11):c.61G>A (p.Gly21Ser)	STK11 (G21S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 2452001	NM_000455.5(STK11):c.62G>C (p.Gly21Ala)	STK11 (G21A)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 1752725	NM_000455.5(STK11):c.62G>T (p.Gly21Val)	STK11 (G21V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 826447	NM_000455.5(STK11):c.64A>G (p.Met22Val)	STK11 (M22V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 826507	NM_000455.5(STK11):c.65T>G (p.Met22Arg)	STK11 (M22R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 486995	NM_000455.5(STK11):c.67del (p.Asp23fs)	STK11 (D23fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 826758	NM_000455.5(STK11):c.69C>G (p.Asp23Glu)	STK11 (D23E)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +2 more	GUncertain significance
Select item 766544	NM_000455.5(STK11):c.69C>T (p.Asp23=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 628078	NM_000455.5(STK11):c.71C>G (p.Thr24Arg)	STK11 (T24R)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 403777	NM_000455.5(STK11):c.71C>T (p.Thr24Met)	STK11 (T24M)	Single nucleotide variant (missense variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 1758741	NM_000455.5(STK11):c.73T>C (p.Phe25Leu)	STK11 (F25L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 486992	NM_000455.5(STK11):c.75C>T (p.Phe25=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 458063	NM_000455.5(STK11):c.76A>G (p.Ile26Val)	STK11 (I26V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1761110	NM_000455.5(STK11):c.78C>A (p.Ile26=)	STK11	Single nucleotide variant (synonymous variant +1 more)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 378674	NM_000455.5(STK11):c.84C>T (p.Arg28=)	STK11	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign/Likely benign
Select item 221001	NM_000455.5(STK11):c.85A>T (p.Ile29Phe)	STK11 (I29F)	Single nucleotide variant (missense variant)	not specified +2 more	GUncertain significance
Select item 480723	NM_000455.5(STK11):c.90C>G (p.Asp30Glu)	STK11 (D30E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 184843	NM_000455.5(STK11):c.90C>T (p.Asp30=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 428766	NM_000455.5(STK11):c.93dup (p.Thr32fs)	STK11 (T32fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 492568	NM_000455.5(STK11):c.93C>A (p.Ser31=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 486994	NM_000455.5(STK11):c.93C>T (p.Ser31=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 237806	NM_000455.5(STK11):c.94A>G (p.Thr32Ala)	STK11 (T32A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 458076	NM_000455.5(STK11):c.96C>T (p.Thr32=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 135930	NM_000455.5(STK11):c.96C>G (p.Thr32=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +3 more	GBenign/Likely benign
Select item 215745	NM_000455.5(STK11):c.99G>A (p.Glu33=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 185412	NM_000455.5(STK11):c.100G>T (p.Val34Phe)	STK11 (V34F)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 184909	NM_000455.5(STK11):c.100G>A (p.Val34Ile)	STK11 (V34I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 412542	NM_000455.5(STK11):c.102C>T (p.Val34=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 141018	NM_000455.5(STK11):c.103A>G (p.Ile35Val)	STK11 (I35V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 744083	NM_000455.5(STK11):c.105C>T (p.Ile35=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 412541	NM_000455.5(STK11):c.105C>A (p.Ile35=)	STK11	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 1786027	NM_000455.5(STK11):c.107dup (p.Tyr36Ter)	STK11 (Y36*)	Duplication (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 1783110	NM_000455.5(STK11):c.106T>C (p.Tyr36His)	STK11 (Y36H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 428760	NM_000455.5(STK11):c.106del (p.Tyr36fs)	STK11 (Y36fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 486991	NM_000455.5(STK11):c.107A>G (p.Tyr36Cys)	STK11 (Y36C)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 486996	NM_000455.5(STK11):c.108C>G (p.Tyr36Ter)	STK11 (Y36*)	Single nucleotide variant (nonsense)	Peutz-Jeghers syndrome +1 more	GPathogenic
Select item 230097	NM_000455.5(STK11):c.108C>T (p.Tyr36=)	STK11	Single nucleotide variant (synonymous variant)	Peutz-Jeghers syndrome +1 more	GLikely benign
Select item 376334	NM_000455.5(STK11):c.109C>T (p.Gln37Ter)	STK11 (Q37*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 628125	NM_000455.5(STK11):c.110A>G (p.Gln37Arg)	STK11 (Q37R)	Single nucleotide variant (missense variant)	Peutz-Jeghers syndrome +1 more	GUncertain significance
Select item 1797410	NM_000455.5(STK11):c.111G>C (p.Gln37His)	STK11 (Q37H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1016480	NM_000455.5(STK11):c.112C>T (p.Pro38Ser)	STK11 (P38S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance

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